Fig. 11

Schematic model for the synergism of IDH1-mutant metabolite D-2-hydroxyglutarate and temozolomide in anti-glioma via down-regulating ITGB4/PI3K/AKT and increasing DNA double-strand break.

Schematic model for the synergism of IDH1-mutant metabolite D-2-hydroxyglutarate and temozolomide in anti-glioma via down-regulating ITGB4/PI3K/AKT and increasing DNA double-strand break.