Fig. 6: D-2HG enhances the anti-proliferative effect of TMZ. | Cell Death Discovery

Fig. 6: D-2HG enhances the anti-proliferative effect of TMZ.

From: IDH1-mutant metabolite D-2-hydroxyglutarate inhibits proliferation and sensitizes glioma to temozolomide via down-regulating ITGB4/PI3K/AKT

Fig. 6

U251 cells were treated with D-2HG (500 μM), TMZ (500 μM), or a combination of the two drugs. Representative images of U251 proliferation (A), DNA replication ability (B), and cell migration (D) taken by a microscope. C Cell cycle detected via flow cytometry.

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