Table 1 Patients characteristics and Cox analysis of prognostic factors of PFS in gliomas from our series.

From: IDH1-mutant metabolite D-2-hydroxyglutarate inhibits proliferation and sensitizes glioma to temozolomide via down-regulating ITGB4/PI3K/AKT

Variables

 

Univariate analysis

Multivariate analysis

Number

HR

95% CI

P-value

HR

95% CI

P-value

Age

<60

390

 

Reference

    

≥60

131

2.9

2–4.1

<0.0001*

1.05

0.67–1.65

0.839086078

Sex

Female

207

 

Reference

    

Male

314

1.1

0.76–1.5

0.72

0.73

0.48–1.12

0.152117301

WHO class

LGG

275

      

HGG

246

7.8

5.1–12

<0.0001*

3.43

1.81–6.5

<0.0001*

IDH1 mutation

No

182

 

Reference

    

Yes

339

0.12

0.081–0.17

<0.0001*

0.25

0.15–0.43

<0.0001*

TMZ

No

31

 

Reference

    

Yes

239

0.83

0.52–1.3

0.45

0.58

0.3–1.12

0.10546914

Radiotherapy

No

28

 

Reference

    

Yes

208

1

0.62–1.7

0.89

1.53

0.8–2.94

0.201164703

Surgical resection

STR

135

0.66

0.44–0.99

0.045*

1.03

0.41–2.6

0.94612077

GTR

365

1.2

0.81–1.7

0.38

1.02

0.45–2.32

0.96177589

Biopsy

21

3.2

1.6–6.3

<0.0001*

   

Tumor location

Bilateral

28

1.9

0.87–4

0.11

1.38

0.49–3.91

0.546238372

Left side

228

1

0.73–1.4

0.92

   

Right side

265

0.9

0.65–1.2

0.53

1.35

0.88–2.07

0.164008474

Tumor site

Parietooccipital

46

2.3

1.5–3.7

<0.0001*

0.88

0.36–2.14

0.783767334

Frontal temporal

416

0.59

0.4–0.86

0.0071*

0.91

0.41–2.02

0.818719069

Ventricle

4

3.00E-07

0-Inf

0.99

3.25E-08

0-Inf

0.994057817

Cerebellum

5

5.7

1.8–18

0.0032*

2.83

0.56–14.18

0.205841435

Other

50

 

Reference

    
  1. LGG low-grade glioma, HGG high-grade glioma, STR subtotal resection, GTR gross total resection.
  2. *Statistically significant difference (P < 0.05).
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