Fig. 1: ATP6V0A2 is downregulated in EIC. | Cell Death Discovery

Fig. 1: ATP6V0A2 is downregulated in EIC.

From: Epirubicin induces cardiotoxicity through disrupting ATP6V0A2-dependent lysosomal acidification and triggering ferroptosis in cardiomyocytes

Fig. 1: ATP6V0A2 is downregulated in EIC.

A Heat map showing differentially expressed genes in NMVMs between control and EPI-treated groups. Low expression is depicted in green, and high expression is depicted in red. B Volcano plot showing the up-regulated and down-regulated genes in response to EPI treatment measured using microarray analysis. Solid symbols indicate genes in which the differential expression was statistically significant. The orange dot represented ATP6V0A2. C, D Immunoblotting images of ATP6V0A2 protein in HL-1 cardiomyocytes treated with DMSO or EPI (2 μM) for 12 h. E The mRNA level of ATP6V0A2 in HL-1 cardiomyocytes treated with EPI (2 μM). F IHC analysis of ATP6V0A2 expression in murine myocardium administrated with DMSO or EPI. Student’s t test was performed for statistical analysis. ***p < 0.001, *p < 0.05.

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