Fig. 2: The effects of ILC2s on innate immunity.
From: Tissue microenvironment induces tissue specificity of ILC2
The effects of ILC2s on innate immunity When infection antigens attack the tissue mucosal barrier, epithelial cells secrete IL-25, TSLP, and IL-33 to activate ILC2 and promote ILC2 to produce Areg. Amphiregulin (Areg) has the function of repairing tissue damage. Activated ILC2 secretes IL-9, IL-13, IL-4 and IL-5. IL-13 induces epithelial eotaxins and endothelial adhesins to promote the recruitment of eosinophil. IL-5 induces eosinophil recruitment in tissues, which could amplify tissue inflammation. IL-9 promotes goblet cell proliferation and increased mucus.
