Fig. 8: IL-8 expression is elevated in HNSCC and BAY-876 reduces TNF-alpha-induced IL-8. | Cell Death Discovery

Fig. 8: IL-8 expression is elevated in HNSCC and BAY-876 reduces TNF-alpha-induced IL-8.

From: GLUT1 inhibitor BAY-876 induces apoptosis and enhances anti-cancer effects of bitter receptor agonists in head and neck squamous carcinoma cells

Fig. 8

A Box plots of pro-inflammatory cytokines expression, showing CXCL8 to be amongst the highest expressed cytokines in HNSCC tumor samples (n = 519) and normal tissue samples (n = 44). Generated using GEPIA2. RNA fold change of CXCL8 in B FaDu and C SCC47 cells after 24-h treatment with TNF-alpha (known IL-8 inducer) ± BAY-876. Fold change is relative to control (untreated). Fold change means ± SD with n = 3 separate passages of cells. 1-way ANOVA with Bonferroni’s posttest comparing Control to TNF-alpha treatment alone and TNF-alpha treatment alone to TNF-alpha + BAY-876. P < 0.05 (*), P < 0.01 (**), P < 0.05 (*), P < 0.01 (**), P < 0.001 (***), and no statistical significance (ns or no indication). TCGA cancer abbreviations shown in Fig. 1 legend.

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