Fig. 6: In Vivo Validation of SVIP Expression Effects on GBM.
From: SVIP reduces IGFBP-2 expression and inhibits glioblastoma progression via stabilizing PTEN
A The schematic diagram of in vivo tumor implantation in nude mice. B Bioluminescence images of nude mice. C Quantification of bioluminescent signal intensities in nude mice. D The Kaplan‒Meier survival curve of nude mice. E Statistics of body weight alteration curves in nude mice. F HE staining of murine brain paraffin sections showing tumorigenesis. G IHC was used to detect the expression of SVIP and IGFBP-2 in murine brain paraffin sections. H The plasma IGFBP-2 expression levels in experimental and control mice were detected by ELISA. Statistical analysis: data were quantified as mean ± SD, n ≥ 3, two tailed student’s t test, P < 0.001, ***; ns, no significance.
