Fig. 4: Effect of rhMFGE8 application on hippocampal neural stem/progenitor cells after SAH. | Cell Death Discovery

Fig. 4: Effect of rhMFGE8 application on hippocampal neural stem/progenitor cells after SAH.

From: MFGE8 promotes adult hippocampal neurogenesis in rats following experimental subarachnoid hemorrhage via modifying the integrin β3/Akt signaling pathway

Fig. 4: Effect of rhMFGE8 application on hippocampal neural stem/progenitor cells after SAH.

A Double immunofluorescence staining with Nestin(green) and MCM2(red) in hippocampus between sham, SAH + vehicle and SAH + rhMFGE8 group. Triangles indicated the nestin positive and MCM2 positive cells. B Double immunofluorescence staining with BrdU(red) and MCM2(green) in hippocampus between sham, SAH + vehicle and SAH+rhMFGE8 group. Arrowheads indicated the MCM2 positive and BrdU positive cells. C, D Quantitative analyses of Nestin positive MCM2 positive cells and BrdU positive MCM2 positive cells in three groups. **P < 0.01 vs sham group, ##P < 0.01 vs SAH + vehicle group, Error bars were represented as mean ± SD. One-way ANOVA, Tukey’s test, n = 3 per group. Scale bar, 100 μm. MCM2, minichromosome maintenance complex component 2.

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