Fig. 6: Knockdown integrin β3 or blocked PI3K/Akt signaling pathway abolished the rhMFGE8 treatment effects on neurological function. | Cell Death Discovery

Fig. 6: Knockdown integrin β3 or blocked PI3K/Akt signaling pathway abolished the rhMFGE8 treatment effects on neurological function.

From: MFGE8 promotes adult hippocampal neurogenesis in rats following experimental subarachnoid hemorrhage via modifying the integrin β3/Akt signaling pathway

Fig. 6: Knockdown integrin β3 or blocked PI3K/Akt signaling pathway abolished the rhMFGE8 treatment effects on neurological function.

A Experimental design, animal groups and time frame of the analyses in experiment 4. B Modified Garcia score and beam balance score show that rhMFGE8 treatment improves the scores, with the effect reversed by int-β3 siRNA and PI3K/Akt inhibitor. C Representative western blot bands and (D–K). Quantitative analyses of MFGE8, int β3, PI3K, p-Akt, Akt, mTOR, cyclin D1, HPCA and DCX at 24 hr after SAH. **P < 0.01 vs sham group; ##P < 0.01 vs. SAH+vehicle group; $$ P < 0.01 vs. SAH + rhMFGE8+ scr siRNA; && P < 0.01 vs. SAH+rhMFGE8 + vehicle. Data were represented as mean ± SD. One-way ANOVA, Tukey’s test, n = 6 per group.

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