Fig. 1: SOD1 gene expression in human GBs.

A, B Analysis of SOD1 and SOD2 expression and median overall survival in GBs using the TCGA GBM database via Gliovis [35]. C Physiological mTORC1 inhibition induced by hypoxia and nutrient deprivation causes a dephosphorylation and activation of SOD1 to potentially improve cell survival (Created with BioRender.com, modified after Tsang et al.). D Expression of SOD1 and SOD1 in human astrocytes, glioma cell lines and primary glioma cells in normoxia without nutrient deprivation were analyzed by immunoblot.