Fig. 5: Palbociclib-treated TRIB3 inhibition decreased the expression of SLC7A11. | Cell Death Discovery

Fig. 5: Palbociclib-treated TRIB3 inhibition decreased the expression of SLC7A11.

From: TRIB3 inhibition by palbociclib sensitizes prostate cancer to ferroptosis via downregulating SOX2/SLC7A11 expression

Fig. 5: Palbociclib-treated TRIB3 inhibition decreased the expression of SLC7A11.

Ferroptosis-related genes were detected in A, B palbociclib treatment, and C, D TRIB3-KD LNCaP and PC3 cells. E the expression of SLC7A11 was evaluated in LNCaP and PC3 TRIB3-OE cells by qRT-PCR assays. F The rescue assay for protein level alteration of SLC7A11 was evaluated in LNCaP TRIB3-OE cells and empty vector control cells with or without palbociclib treatment. The data are presented as the mean ± S.D. of at least three independent experiments. *P < 0.05, **P < 0.01.

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