Fig. 1: Total RNA m6A modification and METTL3 expression are decreased in DS cardiac tissues. | Cell Death Discovery

Fig. 1: Total RNA m6A modification and METTL3 expression are decreased in DS cardiac tissues.

From: Methyltransferase METTL3 governs the modulation of SH3BGR expression through m6A methylation modification, imparting influence on apoptosis in the context of Down syndrome-associated cardiac development

Fig. 1

A Decreased global m6A level in total RNA isolated from DS fetal cardiac tissue compared with control via an m6A enzyme-linked immunosorbent assay kit. B Western blotting analysis of METTL3, METTL14, FTO and YTHDF3 in fetal cardiac tissues of four DSs and three controls. The GAPDH was used as an internal control. C Quantification of western blotting for different proteins. D The abundance of m6A modified SH3BGR mRNA was reduced in DS compared with control sample. Data were presented as mean ± SD of three independent experiments. *p < 0.05; **p < 0.01 compared with the control group.

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