Fig. 3: The expression of SH3BGR is dysregulated in DS cardiac tissues. | Cell Death Discovery

Fig. 3: The expression of SH3BGR is dysregulated in DS cardiac tissues.

From: Methyltransferase METTL3 governs the modulation of SH3BGR expression through m6A methylation modification, imparting influence on apoptosis in the context of Down syndrome-associated cardiac development

Fig. 3

A RNA-seq data showed increased expression of SH3BGR in DS cardiac tissues. B RT-qPCR analysis confirmed that SH3BGR mRNA was increased in DS tissues. C, D SH3BGR protein level was analyzed by western blotting in DS and control samples. Data were presented as mean ± SD of three independent experiments. **p < 0.01 compared with the control group. E RNA-seq data showed upregulated expression of SH3BGR in heart tissues of Dp16 mice.

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