Fig. 4: METTL3 deficient mice displayed Cardiac left ventricular malformation. | Cell Death Discovery

Fig. 4: METTL3 deficient mice displayed Cardiac left ventricular malformation.

From: Methyltransferase METTL3 governs the modulation of SH3BGR expression through m6A methylation modification, imparting influence on apoptosis in the context of Down syndrome-associated cardiac development

Fig. 4

A Schematic diagram of generating Mettl3f/f mice. B Western blotting analysis confirming the knockout efficiency of Mettl3 in the hearts from cKO mice. Gapdh served as an internal control. C Number of mice genotyped in pups and embryos when mating Mettl3f/f mice with Myh6-Cre transgenic mice. Representative HE staining of the hearts from cKO mice and control mice at E14.5 D-D’, E16.5 E-E’, E18.5 F-F’. D”, E”, F” Left wall thickness in cKO and control embryos were measured and calculated respectively.

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