Fig. 6: A mechanistic roadmap explaining how RT upregulates CD73 and how combination therapy exerts antitumor effects.
From: Blockade of CD73 potentiates radiotherapy antitumor immunity and abscopal effects via STING pathway
A Schematic diagram of RT up-regulates CD73 in MC38 cells through ATR-Chk1-STAT3 pathway and the combination of αCD73 and RT triggers CD8 + T cell-mediated adaptive immune responses by potentiating activation of the cGAS-STING pathway and type I IFN production. B The schematic summary of synergistic mechanism between αCD73 + RT. The combination of αCD73 and RT (right) significantly reduces the infiltration of TAM, MDSCs, and Tregs, while augmenting the infiltration of mature DCs and CD8 + T cells. Furthermore, it stimulates the generation of TNF-α, IFN-γ, and GzmB and reduces T-cell exhaustion compared to the control group (left).
