Fig. 1: Types of PTMs (created with BioRender.com).
From: Regulation of HNRNP family by post-translational modifications in cancer
(1) classical modifications that are abundant in cells and play key roles in cellular energy metabolism, lipid metabolism, ketone body metabolism, and amino acid metabolism. (2) Modifications present only in cysteine. When cells are subjected to oxidative stress, oxidation modification on cysteine may occur as a response. (3) Membrane proteins glycosylation plays an important role in the protection, stability, and barrier of cell membranes. (4) Novel acylation modifications are involved in epigenetic regulation, which plays a role in DNA damage repair, histone acylation modification, chromatin packaging, and so on.
