Table 1 A summary table of the HNRNP family.

A
	Site	Domain	Kinase	disease	Function	Target	Ref.
A0	Ser84-P	RRM	MAPKAPK2	NSCLC	Response to DNA damage Translational regulation mRNA stability	p27kip1 Gadd45α	[42]
A1	Lys3-Ub	N-terminal	TRAF6	CML	Splicing	Arhgap1	[17]
A1	Ser4-P Ser6-P	N-terminal	S6K2	CRC BC	Translational regulation mRNA transportation Splicing	Bcl-xL, xIAP PKM	[44, 45]
A1	Lys8-Ub	N-terminal	ZFP91	HCC	Splicing	PKM	[50]
A1	Lys113-SUMO	RRM	SAE2 UCB9	PDAC BLCA	Lymphangiogenesis	KRAS ESCRT	[47, 199]
A1	Ser199-P Arg218/225-Me	RGG	Akt PRMT5	GBM	IRES-trans-acting factors activity	Cyclin D1 c-MYC	[48, 49]
A2/B1	Lys274/305-Ub	—	VHLα	RCC	Degradation	c-MYC	[59]
A2/B1	Lys108-SUMO	RRM	UCB9	GBM	Exosomal packaging and sorting	STAT3	[56]
A2/B1	Lys108-SUMO	RRM	UCB9	NSCLC	Lymphangiogenesis, lymphatic metastasis	PROX1	[57]
A2/B1	Lys27-Ub Lys48-Ub	RRM	FBXO11	HCC	Degradation	FASN ACC1	[58]
C	Tyr57-P	RRM	uPA	NSCLC	mRNA stability	uPAR	[68]
CL	Lys175-SUMO	—	UBA2	GBM	Translational regulation	FOXD1	[72]
D	Ser83/87-P Thr91-P	—	mTORC2	—	Phosphorylate Akt mRNA stability mRNA binding	Akt	[75,76,77]
D	Arg-Me (*4) (in the RGG)	RGG	—	—	Maintain RGG activity	VEGF	[79]
E1	Ser43-P	KH1	Akt	NSCLC BC	Promote the EMT	TGF-β	[200]
E1	Thr60/127-P	KH1/KH2	Pak1	BC	mRNA binding Translational regulation Splicing	Caper-α	[18]
E2	Ser173/189-P, Ser272-P, Thr213-P	—	MAPK^ERK1/2	CML	mRNA binding Translational regulation	C/EBPα G-CSFR	[91]
F	Lys98-Ac/Ub, Lys224-Ac/Ub	RRM	—	BC	Splicing	Bcl-x	[19]
G	Thr216-P	SPRY	TAK1	—	—	—	[101]
I	Ser16-P	NLS	PKA	—	Nucleoplasmic transport Localization	—	[111]
I	Thr138-P	RRM	Lkb1	tumorigenesis	Splicing	Scf	[112]

B
	Site	Domain	Kinase	disease	Function	Target	Ref.
K	Cys132-Redox	—	—	tumorigenesis	Transcriptional Inhibit	HSF1	[146, 147]
K	Ser116-P	—	Akt	PCa	mRNA binding	AR	[149, 201]
K	Ser116 Thr120 related	—	FBXW7	PDAC	Recognizing and binding	miR-223	[202]
K	Lys63-Ub	KH1	SCF^Fbxo4	SKCM	mRNA binding	c-MYC	[140]
K	Ser284/353-P	KNS	MAPK^ERK1/2	NPC	mRNA stability Localization	—	[143,144,145]
K	Lys422-SUMO	KH3	Pc2 PIAS3	CRC	HNRNPK-p53-p21	p53	150,151,152]
K	Arg296/299-Me Ser302-P	—	—	—	Cell Apoptosis	—	[153]
K	Arg296/299-Me Ser379-P	—	PRMT1	TNBC	Cell Migration	β-catenin	[13]
K	Tyr458-P	C-terminal	c-Src	—	mRNA binding	DICE	[203]
L	Ser52-P	—	AKT	NSCLC	mRNA binding, Splicing	caspase-9	[118, 119]
L	Tyr359-P	—	Anaerobic	tumorigenesis	Splicing, Localization	VEGFA	[120,121,122]
L	Ser544-P	RRM	CaMkIV	tumorigenesis	mRNA binding	CaRRe	[123, 124]
L	Ub	—	FBXO16	OV	degradation	—	[125]
M	Ser574-P	—	P38/MAPK	Innate immunity	mRNA binding	IL-6	[159]
P	Tyr6/296-P	QGSY/NES	EGFR	fibrotic diseases	Localization Transcriptional regulation	collagenVI	[161]
P	Ser182/183-P	RGG	casein kinase1δ/ε	ALS AD PD	Solubility of proteins	—	[162]
P	Ser256-P	RGG	PKCβII	CML	Protein stability	—	[165]
P	Lys315/316-Ac, Lys510-Ac	RRM, NLS	CBP(P300)	ALS	mRNA binding Localization	— Transportin1	[166]
P	Lys333-SUMO	RRM	UBC9	GBM	Protein stability	ATG4D	[167]
P	Arg-Me	NLS	PRMT1	—	Localization	—	[168]
P	Tyr526-P	C-terminal	Abl	—	Localization	—	[169]
Q	—
R	—
U	Ser59-P	—	DNA-PK PLK1	—	Response to DNA damage Chromosome alignment Chromosome segregation	—	[177,178,179]

This table contains the types of post-translational modifications, the sites where the post-translational modifications occur, and the domains, the associated cancer or disease types, functions, and downstream targets. —: No progress or results.

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