Fig. 8: Schematic illustration of circMETTL3 promoting the M1 polarization of macrophages through positive METTL3-156aa/LDHA/LA/SRSF10 feedback. | Cell Death Discovery

Fig. 8: Schematic illustration of circMETTL3 promoting the M1 polarization of macrophages through positive METTL3-156aa/LDHA/LA/SRSF10 feedback.

From: CircMETTL3-156aa reshapes the glycolytic metabolism of macrophages to promote M1 polarization and induce cytokine storms in sHLH

Fig. 8

Exosome-CircMETTL3 encodes the protein METTL3-156aa which binds to LDHA, promoting glycolysis in macrophages. The metabolite lactate increase the level of SRSF10 by lactylation, leading to METTL3 pre-mRNA transcription and back-splicing under the action of SRSF10, forming a positive feedback on circMETTL3 production in monocytes, resulting in M1 polarization and cytokines storm.

Back to article page