Fig. 2: MACC1 is a pivotal regulator for the non-CSCs dedifferentiation of lung cancer in vitro. | Cell Death Discovery

Fig. 2: MACC1 is a pivotal regulator for the non-CSCs dedifferentiation of lung cancer in vitro.

From: MACC1 ablation suppresses the dedifferentiation process of non-CSCs in lung cancer through stabilizing KLF4

Fig. 2: MACC1 is a pivotal regulator for the non-CSCs dedifferentiation of lung cancer in vitro.The alternative text for this image may have been generated using AI.

A Schematic outline of the experimental procedure in Dox-inducible MACC1 overexpression cells (A549) or knockdown cells (H1299). A549 ALDH- (sorted) and H1299 ALDH- (sorted) were cultured in the absence or presence of Dox for 7 days, B–E the percentage of ALDH+ cells were determined using FACS. comparison of sphere-forming ability (F–K), colony-forming numbers and cell viability (L–Q) were analyzed following MACC1 interference (absence or presence of Dox). *P < 0.05 **P < 0.01***P < 0.001, two-tailed Student’s t-tests and ANOVA. Error bars: mean ± SD. Scale bars, 100 μm.

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