Fig. 5: KLF4 is a key effector of MACC1 mediated non-CSCs dedifferentiation in lung cancer. | Cell Death Discovery

Fig. 5: KLF4 is a key effector of MACC1 mediated non-CSCs dedifferentiation in lung cancer.

From: MACC1 ablation suppresses the dedifferentiation process of non-CSCs in lung cancer through stabilizing KLF4

Fig. 5: KLF4 is a key effector of MACC1 mediated non-CSCs dedifferentiation in lung cancer.The alternative text for this image may have been generated using AI.

A–D Validation of KLF4 of mRNA and protein level were examined following MACC1 silence in H1299 cell line. column graph displayed relative quantification of KLF4 mRNA and protein after three replicates, *P < 0.05, **P < 0.01. Error bars: mean ± SD. E shRNA-mediated KLF4 suppression in both H1299-shNC and H1299-shMACC1 cells. MACC1 and KLF4 expression levels were examined by western blot. Sphere-forming abilities (F, G), colony-forming ability (H, I) and cell viability (J) were compared. *P < 0.05, ***P < 0.001. Error bars: mean ± SD Scale bars, 100 μm. The comparison of data among the above groups was conducted using ANOVA.

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