Fig. 4: iASPP cancer mutants do not induce aggregation.
From: Cardiocutaneous syndrome is caused by aggregation of iASPP mutants
A Lollipop diagram showing localization and frequency of reported iASPP mutations in cancer (taken from cBioPortal: https://bit.ly/3yrAWvA). B BN PAGE (top) and SDS PAGE (bottom) of selected iASPP mutants transiently transfected into H1299 cells. Western Blots were evaluated using an anti-Myc antibody. C Superimposed crystal structures of the iASPP CTD (PDB: 2VGE; AA616-823) and the iASPP CTD bound to the p53 DBD (PDB: 6RZ3; iASPP: AA657-823; p53: AA91-291). Mutations included in (B) are visualised as sticks in orange.
