Fig. 4: Forced expression of CRAT attenuated OC growth and metastasis in vivo. | Cell Death Discovery

Fig. 4: Forced expression of CRAT attenuated OC growth and metastasis in vivo.

From: CRAT downregulation promotes ovarian cancer progression by facilitating mitochondrial metabolism through decreasing the acetylation of PGC-1α

Fig. 4

A Tumor growth rate of xenograft tumors (n = 6 mice per group) developed from CRAT stable knockdown (shCRAT) or control (shCtrl) HEY cells. B The weight of tumors was compared in shCRAT and shCtrl groups (n = 6 mice per group). C CRAT expression was detected by immunohistochemistry (IHC) analysis in xenograft tumors (n = 6 mice per group). Scale bar, 50 μm. D Ki-67 expression was detected by immunohistochemistry (IHC) analysis in xenograft tumors (n = 6 mice per group). Scale bar, 50 μm. E TUNEL staining assay for evaluation of cell apoptosis in xenograft tumors (n = 6 mice per group). Scale bars, 20 μm. F Lung metastases in nude mice were compared between shCRAT and shCtrl groups. Scale bars, 50 μm. (n = 6 mice per group). *P < 0.05.

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