Fig. 5: CRAT knockdown promoted the growth and metastasis of OC cells. | Cell Death Discovery

Fig. 5: CRAT knockdown promoted the growth and metastasis of OC cells.

From: CRAT downregulation promotes ovarian cancer progression by facilitating mitochondrial metabolism through decreasing the acetylation of PGC-1α

Fig. 5

A, B Knockdown of CRAT was determined by qRT-PCR and western blot analysis in two OC cell lines named A2780 and ES2 (siCRAT, siRNA targeting CRAT; siCtrl, control siRNA). C–E MTS cell viability C, colony formation D and EdU staining E assays in A2780 and ES2 cells with CRAT knocked-down. F, G Cell migration capability was evaluated by wound healing F and transwell migration G assays in A2780 and ES2 cells with CRAT knocked-down. H Cell invasion capability was evaluated by transwell invasion assays in A2780 and ES2 cells with CRAT knocked-down. Data presented as mean ± SEM of triplicate independent experiments, *P < 0.05.

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