Fig. 5: Upregulation of PLIN2 accelerates in vivo metastasis of OSCC cells and predicts poor prognosis of OSCC patients. | Cell Death Discovery

Fig. 5: Upregulation of PLIN2 accelerates in vivo metastasis of OSCC cells and predicts poor prognosis of OSCC patients.

From: Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition

Fig. 5: Upregulation of PLIN2 accelerates in vivo metastasis of OSCC cells and predicts poor prognosis of OSCC patients.The alternative text for this image may have been generated using AI.

A In vivo imaging results showed that HSC3 cells stably overexpressing PLIN2 injected into the nude mice through the tail vein could form tumor metastases in the lungs. B HE staining results presented significant tumor metastases in the lungs of nude mice injected with HSC3 cells stably overexpressing PLIN2 and the corresponding PAN-CK staining confirmed that the lung metastases were of epithelial origin. Bar: 300 μm. C The lung metastasis rate of nude mice in the experimental group was significantly higher than that in the control group (n = 15). D IHC staining of PLIN2 showed that high expression of PLIN2 was detected in tumor metastasis sites in lung tissues. Bar: 200 μm. E Analysis of TCGA database showed that PLIN2 was highly expressed in OSCC patients with lymph node metastasis. F, G Analysis of TCGA database showed that OSCC patients with high PLIN2 expression possessed shorter overall survival time and metastasis-free survival time than those with low PLIN2 expression. H Analysis of the GSE65858 dataset showed that PLIN2 was highly expressed in OSCC patients with lymph node metastasis. I Analysis of the GSE65858 dataset showed that OSCC patients with high PLIN2 expression possessed a shorter overall survival time than those with low PLIN2 expression. J Comprehensive analysis of TCGA and GDSC databases revealed that tumor chemotherapy drugs (1S,3 R) -RSL3 and ML-210 had higher sensitivity in OSCC patients with high PLIN2 expression. *P < 0.05. GDSC: Genomics of Drug Sensitivity in Cancer.

Back to article page