Fig. 2: TMEM45A inhibits the cell cycle arrest, apoptosis and promotes proliferation in BRCA cells. | Cell Death Discovery

Fig. 2: TMEM45A inhibits the cell cycle arrest, apoptosis and promotes proliferation in BRCA cells.

From: TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer

Fig. 2

A Cell cycle analysis by Flow Cytometry showing the cell cycle distribution under 24 h of treatment with vehicle (DMSO) or 1 μM palbociclib and statistical analysis are shown below. B Cell apoptosis assay by Annexin-V/PI dual staining under 24 h of treatment with vehicle (DMSO) or 1 μM palbociclib and statistical analysis are shown on the right side. C The results of the colony formation assay under 14 days treatment with vehicle (DMSO) or 1 μM palbociclib and statistical analysis are shown on the right side. D 5-ethynyl-2′-deoxyuridine (EdU) incorporation assay show the proliferative ability of BRCA cells under 24 h of treatment with vehicle (DMSO) or 1 μM palbociclib and statistical analysis are shown on the right side. *P < 0.05, **P < 0.01, ***P < 0.001. ns, not significance.

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