Fig. 6: Drg2 deficiency inhibits osteoclast differentiation and function. | Cell Death Discovery

Fig. 6: Drg2 deficiency inhibits osteoclast differentiation and function.

From: Rac1-dependent regulation of osteoclast and osteoblast differentiation by developmentally regulated GTP-binding 2

Fig. 6

A BMMs derived from wild-type or Drg2 knockout mice were cultured in M-CSF and RANKL. The osteoclast numbers were determined after TRAP staining. N = 3. Scale bar, 200 µm. B BMMs were cultured in M-CSF and RANKL on the hydroxyapatite coating plate. The numbers of resorption pits were determined. N = 3. Scale bar, 200 µm. C BMMs derived from wild-type or Drg2 knockout mice were cultured in M-CSF and RANKL for the indicated times. The mRNA levels were analyzed using quantitative PCR. Data represent the mean ± SD of triplicate samples. #P < 0.05, **P < 0.001 vs. control.

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