Fig. 6: LC3 and TC-PTP expressions in human skin tumors.
From: Loss of TC-PTP in keratinocytes leads to increased UVB-induced autophagy
A Representative immunohistochemical staining of LC3 and TC-PTP in normal human skins (n = 8), squamous cell carcinomas (SCCs) (n = 33), and basal cell carcinomas (BCCs) (n = 5). Scale bar: 10 µm. B Quantification of LC3 expression by immunohistochemistry (IHC) scoring. Percentage of cells showing more than IHC score 3. LC3 expression levels from each section were assessed as described in Methods. **P < 0.01 by Mann–Whitney U-test. C Quantification of LC3 expression by immunohistochemistry scoring in different grades of SCCs. **P < 0.01 by Mann–Whitney U-test. D Representative immunohistochemical staining of LC3 and TC-PTP in SCCs. Scale bar: 10 µm. E Representative immunohistochemical staining of LC3 and TC-PTP in BCCs. Scale bar: 10 µm. F Correlation scatter plots for expression of LC3 and TC-PTP in human skin tumors. The Pearson correlation coefficient was calculated with a two-tailed P value. r = −0.57, P < 0.0006.
