Fig. 4: LINC02418 plays a positive role in the regulation of the Wnt/β-catenin signaling pathway in CRC. | Cell Death Discovery

Fig. 4: LINC02418 plays a positive role in the regulation of the Wnt/β-catenin signaling pathway in CRC.

From: m6A-modified LINC02418 induces transcriptional and post-transcriptional modification of CTNNB1 via interacting with YBX1 and IGF2BP1 in colorectal cancer

Fig. 4

A GSEA analysis suggested that there is a positive correlation between LINC02418 and the Wnt signaling pathway in TCGA COADREAD dataset. B–C mRNA level of β-catenin and typical Wnt signaling pathway-targeted genes were detected by qPCR after LINC02418 overexpression in RKO and Caco2 cells. D–E mRNA level of β-catenin and typical Wnt signaling pathway-targeted genes were detected by qPCR after LINC02418 overexpression in RKO and HCT116 cells. F–G Protein level of β-catenin and typical Wnt signaling pathway-targeted genes were detected by western blot after LINC02418 overexpression in RKO and Caco2 cells. H–I Protein level of β-catenin and typical Wnt signaling pathway-targeted genes were detected by western blot after LINC02418 knockdown in RKO and HCT116 cells.

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