Fig. 6: KEGG pathway enrichment analysis.

A Bar plot showing significant pathways associated with differentially expressed genes between primary breast cancer and brain metastatic samples. Key pathways include HIF-1 signaling, glycolysis/gluconeogenesis, and antigen processing and presentation. B Dot plot indicating the significance of these pathways, with gene ratios and adjusted p-values. C Network plot illustrating the connections between key genes and their associated pathways, highlighting the roles of metabolic reprogramming and immune evasion in brain metastasis.