Table 1 Inhibitors of potential therapeutic targets in lipid metabolism in glioblastoma.
From: Lipid metabolism: the potential therapeutic targets in glioblastoma
Inhibitors | Targets | Functions | References |
|---|---|---|---|
Orlistat, Cerulenin and C75 | FASN | Induction of apoptosis and autophagy | [23] |
Cerulenin | FASN | Induction of apoptosis and S-phase cell cycle arrest | [25] |
SB‐FI‐26 | FABP7 | Inhibition of glioblastoma slow‐cycling cell migration | [39] |
Statin | HMGCR | Inhibition of cell proliferation and induction of autophagy | [55] |
Induction of apoptosis | [56] | ||
Avasimibe | ACAT1 | Enhancement of ferroptosis sensitivity | [80] |
Inhibition of cell proliferation and induction of apoptosis | |||
A-922500 | DGAT1 | Induction of apoptosis | [89] |
AA452 | PPARα | Induction of cell death, enhancement of radiosensitivity, and inhibition of migration | [100] |
Fatostatin | SCAP | Inhibition of cell proliferation | [120] |
Lycorine | SCAP | Inhibition of cell proliferation and migration | [122] |
Berberine | SREBP-1 | Inhibition of cell proliferation, migration and invasion | [125] |
Phytol | SREBP-1 | Inhibition of cell viability | [127] |
