Fig. 5: Downregulated Txnip expression influences glucose utilized efficiency and promotes glycolysis metabolic reprogramming.
From: Targeting Txnip-mediated metabolic reprogramming has therapeutic potential for osteoarthritis
A GO enrichment analysis of negative control and Txnip-silenced ATDC5 treated with 7 days chondrogenesis induction. (n = 3 per group, 1 technical replicate of 3 biological replicates). B Heatmap displayed the expression change of genes related to extracellular matrix organization and chondrocyte differentiation. (n = 3 per group, 1 technical replicate of 3 biological replicates). C Glucose catabolic process by GSEA analysis of negative control and Txnip-silenced ATDC5 treated with 7 days chondrogenesis induction. (n = 3 per group, 1 technical replicate of 3 biological replicates). D Heatmap displayed the expression change of genes related to glucose catabolic process. (n = 3 per group, 1 technical replicate of 3 biological replicates). E EACR of negative control and Txnip-silenced ATDC5 treated with 7 days chondrogenesis induction. F Quantification of EACR related glycolysis, glycolytic reserve, and glycolytic capacity. (n = 3 per group, 1 technical replicate of 3 biological replicates). Data are expressed as mean \(\pm\) SD (ns, no significance; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.001 by Student’s t-test (F)).
