Fig. 2: RIPK1 is involved in regulating the occurrence of necroptosis processes.
From: Exploring necroptosis: mechanistic analysis and antitumor potential of nanomaterials
RIPK1 is involved in the signaling of multiple signaling pathways and is even related to survival pathways. In the necroptosis pathway, RIPK1 plays a crucial role, not only in the recruitment of death domains, but also in the formation of necrosome complexes, thereby activating Caspase-dependent and Caspase-independent cell death pathways.
