Fig. 4: SAFit fails to restrain melanoma growth in vivo. | Cell Death Discovery

Fig. 4: SAFit fails to restrain melanoma growth in vivo.

From: Exploring the potential of selective FKBP51 inhibitors on melanoma: an investigation of their in vitro and in vivo effects

Fig. 4: SAFit fails to restrain melanoma growth in vivo.

a Tumors excised were photographed and measured. The graph on the right represents the volume measures. b Western blot assay of TβR1, PD-L1 and active Caspase 3 (analyzed on a blot run in parallel) expression levels in SAFit 2 -untreated and -treated tumors. β-Actin (analyzed on a blot run in parallel) was used as loading control. Full length western blots are shown as Supplemental Material. A densitometric analysis of bands was performed using ImageJ 1.42q for Macintosh. c Relative normalized expression values of CCND1, TGFβ and PDL1 mRNA levels in SAFit-treated or untreated tumors. Lower, Western blot of protein extracted from the tumors for cyclin D and TGF-β assay. Full gels are shown as Supplemental Material.

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