Fig. 7: Working model. | Cell Death Discovery

Fig. 7: Working model.

From: NRF1 coordinates mitochondrial adaptations to dampen intracellular ROS and inflammatory responses during ischemia reperfusion

Fig. 7: Working model.

OGD/R triggers mitochondria to produce high levels of ROS, which activates the mTORC1 signaling pathway leading to the activation of NRF1. Activated NRF1 translocates to the nucleus, inducing genes regulating proteasome subunits to promote mitochondrial fission, which reduces mtROS production and facilitates mitophagy. Activated NRF1 also upregulates genes encoding mitophagy regulators to directly drive mitophagy. Thus, NRF1 coordinates mitochondrial adaptations that preserves mitochondrial integrity and reduces ROS levels and cellular stress. (Created with BioRender.com).

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