Fig. 2: Mechanism by which ANXA2-induced autophagy inhibits apoptosis in tumour cells.
From: ANXA2 in cancer: aberrant regulation of tumour cell apoptosis and its immune interactions
ANXA2 inhibits apoptosis primarily through two mechanisms involving autophagy. On the one hand, ANXA2 enhances ATG7 transcription via an mTORC1-dependent pathway or facilitates transcription factor EB (TFEB) nuclear translocation to regulate Atg proteins, thereby modulating autophagy. On the other hand, ANXA2 induces autophagy by promoting plasma membrane invagination to form Atg16L+ vesicles or by regulating UNC51-like kinase-1 (ULK1) localization to facilitate autophagosome formation.
