Fig. 1: Reduced c-Cbl expression in the substantia nigra of aged mice, MPTP-treated mice and PD patients.
From: The E3 ligase c-Cbl modulates microglial phenotypes and contributes to Parkinson’s disease pathology
A c-Cbl protein expression patterns in the SN of aged mice at different months. B Quantification of c-Cbl protein levels normalized to GAPDH in each group (n = 3). C c-Cbl protein expression in the SN of MPTP-treated mice versus saline-treated controls. D Quantification of c-Cbl protein levels normalized to β-actin (n = 6). E Bioinformatics analysis of c-Cbl mRNA levels in the SN of healthy controls (n = 6) and PD patients (n = 16) using the NCBI database (Reference Series: GSE7307). Data expressed as mean ± SEM; **p < 0.01, ***p < 0.001 vs. 1 month-old group. ###p < 0.001 vs. MPTP group.
