Fig. 5: Transcriptomic profiling of the substantia nigra reveals c-Cbl-dependent microglial regulation. | Cell Death Discovery

Fig. 5: Transcriptomic profiling of the substantia nigra reveals c-Cbl-dependent microglial regulation.

From: The E3 ligase c-Cbl modulates microglial phenotypes and contributes to Parkinson’s disease pathology

Fig. 5

A Heatmap and GO analysis of microglia-related differentially expressed genes (DEGs) between 3 month-old WT and c-Cbl-/- mice (n = 4-5). B Volcano plot of DEGs in the SN of WT and c-Cbl-/- mice. C The top 20 enriched KEGG pathways are displayed as bubble charts. D qPCR validation of Trem2, C1qa, C1qb and C1qc expression in the SN of WT and c-Cbl-/- mice (n = 3). Data expressed as mean ± SEM; *p < 0.05, **p < 0.01 vs. WT group.

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