Fig. 1: MMP1 expression and its correlation with tumor metastasis in pan-cancer analysis. | Cell Death Discovery

Fig. 1: MMP1 expression and its correlation with tumor metastasis in pan-cancer analysis.

From: Decoding the impact of MMP1+ malignant subsets on tumor-immune interactions: insights from single-cell and spatial transcriptomics

Fig. 1

A MMP1 expression levels across multiple tumor types demonstrate a strong positive correlation with tumor metastasis. B Comparative analysis of MMP1 expression between normal and tumor tissues, showing significant upregulation in tumors. C Correlation between MMP1 expression and copy number alterations, indicating a progressive increase from homozygous deletions to high-copy number amplifications. D Immune response analysis of tumors with MMP1 overexpression, revealing a more robust immune activation in high MMP1 groups. E–M Spatial transcriptomic analysis of MMP1 expression in tumor microenvironments, highlighting its localization in specific malignant cell subpopulations and its strong association with tumor cell clusters. N The expression differences of MMP1 between the malignant (Mal) and non-malignant (nMal) regions.

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