Fig. 3: MMP1’s role in immune infiltration, immune cycle disruption, and ligand-receptor signaling in the tumor microenvironment. | Cell Death Discovery

Fig. 3: MMP1’s role in immune infiltration, immune cycle disruption, and ligand-receptor signaling in the tumor microenvironment.

From: Decoding the impact of MMP1+ malignant subsets on tumor-immune interactions: insights from single-cell and spatial transcriptomics

Fig. 3

A Immune infiltration analysis using multiple algorithms revealed that MMP1 promotes increased macrophage infiltration while reducing CD8+ T-cell infiltration. B Immune cycle analysis suggested that MMP1 impaired T-cell function across four common tumor types. C, D Single-cell analyses of breast cancer (BRCA, GSE148673) and colorectal cancer (CRC, EMTAB8107) demonstrated that MMP1 expression is predominantly localized in malignant cells, macrophages, and T cells. E, J Cell communication analysis indicates that MMP1+ malignant cells exhibit stronger outgoing signals compared to MMP1- malignant cells. F, K Ligand-receptor pathway analyses showed that MMP1+ malignant cells exerted strong regulatory effects on CD8+ T-cell activity through the CXCL16-CXCR6 signaling axis and on macrophages through the ANXA1-FPR3 signaling axis. G, L ST analysis of brain metastases from breast cancer and liver metastases from colorectal cancer. H, M The CXCL16-CXCR6 axis’s suppressive effect on CD8+ T cells. I, N The ANXA1-FPR3 axis’s enhancement of macrophage activity.

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