Fig. 5: TET1 and KLF4 as key transcriptional regulators of MMP1 and the role of TET1 mutations in tumor progression. | Cell Death Discovery

Fig. 5: TET1 and KLF4 as key transcriptional regulators of MMP1 and the role of TET1 mutations in tumor progression.

From: Decoding the impact of MMP1+ malignant subsets on tumor-immune interactions: insights from single-cell and spatial transcriptomics

Fig. 5

A, B KnockTF 2.0 database analysis identified TET1 as the most significant activator and KLF4 as the most significant repressor transcription factor of MMP1. C TET1 exhibited a high mutation frequency across various tumor types, with missense mutations being the most prevalent type. D–G Gene mutation and pathway analyses demonstrated a significant association between mutant TET1 and the EMT pathway in BRCA, COAD, LUAD, and KIRC.

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