Fig. 2: Differential effects of artemsinin and its derivatives in LUAD and LUSC. | Cell Death Discovery

Fig. 2: Differential effects of artemsinin and its derivatives in LUAD and LUSC.

From: Artemisinin derivatives differently affect cell death of lung cancer subtypes by regulating GPX4 in patient-derived tissue cultures

Fig. 2

HE staining reveals differential effectivity. Shown are representative pictures of baseline (native tissue) the culture control (CTR) and each treatment performed of one patient with adenocarcinoma (#16, Bars = 100 µm, A) and one patient with squamous cell carcinoma (#18, Bars = 100 µm, B). LUAD proliferation under treatment does decrease after DHA and ATS supplementation, but the cParp expression does not alter (N = 5, C). The tumor vitality score demonstrate that two to three PDTC do not obtain benefit of the treatment (D). LUSC proliferation under treatment does decrease after DHA and ATS supplementation, although not significant, cParp expression was elevated in some PDTC. (N = 6, E). The tumor vitality score demonstrate that all PDTC reduce the tumor vitality under DHA treatment (F). The percentage of the respective control (100%) is given, to demonstrate inter-tissue variability control variances are shown. The median of each condition is indicated. (++Mann–Whitney U-test, p < 0.005 vs. CTR, **Kruskal–Willis test with Dunn´s correction p < 0.005 vs. CTR).

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