Fig. 3: Interplay between MYB and MAFB in MLL-rearranged AML.
From: MAFB: a key regulator of myeloid commitment involved in hematological diseases
Schematic representation showing MYB direct recruitment to MAFB promoter to repress it, resulting in more proliferative and aggressive disease (left panel). Ablation of MYB expression leads to reactivation of MAFB expression with a consequent block of proliferation and activation of myeloid maturation.
