Table 1 List of compounds and small molecule inhibitors with reported direct or indirect effects on MAFB expression or transcriptional activity.
From: MAFB: a key regulator of myeloid commitment involved in hematological diseases
Compound | Inhibited target | Effect on MAFB | Outcome | Reference |
|---|---|---|---|---|
IBS003214 | c-Maf | Reduction of transcriptional activity | Inhibition of proliferation in multiple myeloma cell lines | Asano et al. [101] |
IBS007125 | c-Maf | Reduction of transcriptional activity | Inhibition of proliferation in multiple myeloma cell lines | Asano et al. [101] |
Monensin | MYB | Gene expression activation | Inhibition of proliferation and induction of myeloid commitment in MLL-rearranged leukemia cell lines | Yusenko et al. [102] |
MYBMIM | MYB | Gene expression activation | Inhibition of proliferation and induction of myeloid commitment in MLL-rearranged leukemia cell lines | Takao et al. [103] |
GSK2033 | LXRα | Overexpression | Macrophages reprogramming in inflammatory conditions | De la Aleja et al. [104] |
Upadacitinib | JAK2 | Overexpression | Macrophages reprogramming in inflammatory conditions | Lopez-Navarro et al. [106] |
