Fig. 3: β-catenin inhibits apoptosis during PS induction in a transcription-independent way. | Cell Death Discovery

Fig. 3: β-catenin inhibits apoptosis during PS induction in a transcription-independent way.

From: β-catenin safeguards cell survival via a transcription-independent mechanism during the induction of primitive streak from hESCs

Fig. 3

A PCA plots of RNA-seq. B Spearman correlation of RNA-seq datasets. C Heatmap of DEGs by comparing the expression of genes in wt and β-cat−/−-1 cells at 0, 2, 3, 4 h after PS induction. The sub-clusters (SC) were indicated on the right. D Enriched pathways revealed by KEGG analysis of genes in each SC in (C). E GO analysis of genes in each SC in (D). F Flow cytometry analysis of cell death after 8-h of PS induction in β-cat−/−-Ctrl, β-cat−/−-FL, and β-cat−/−-ΔC cells. Data are represented as mean ± SEM; n = 3; n.s., non-significant; ***p < 0.001; one-way ANOVA followed by Tukey’s post hoc.

Back to article page