Fig. 2 | Cell Death Discovery

Fig. 2

From: The Nrf2-HMOX1 pathway as a therapeutic target for reversing cisplatin resistance in non-small cell lung cancer via inhibiting ferroptosis

Fig. 2

Transmission electron microscopy images of lung cancer cells, including A549/DDP (A, C, E) and A549 cells (B, D, F). The cells were treated with DMSO (A, B), the ferroptosis inducer erastin (10 μM), or cisplatin (20 μM) (E, F) for 48 h. The white arrowheads indicate alterations in mitochondrial ultrastructure, characterized by smaller mitochondria, less tubular morphology, and darker-stained membranes with distinct disruption of inner membrane folding. At least 10 cells were examined per treatment condition. Scale bar = 1 μm.

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