Table 1 Differentiation of known morphological and physiological hallmarks in apoptotic programmed cell death (apopt. PCD), autosis as a representative of non-apoptotic programmed cell death (non-apopt. PCD) and comparison with the results after TG treatment in RBL-1 cells.
Morphological hallmarks | Apopt. PCD | Non-Apopt. PCD (Autosis) | Thapsigargin |
|---|---|---|---|
Nuclear fragmentation | Yes | No | No |
Apoptotic bodies | Yes | No | No |
ER swelling | Yes | Unclear | ER alterations/anomalies |
Chromatin condensation | Yes | Mild chromatin condensation | Mild chromatin condensation |
Mitochondrial alterations | Dilatation | Dilatation, degradation | Dilatation, cristae degradation |
Vesicles and vacuolation | No | Yes | Yes |
Ballooning of perinuclear space | No | Yes | Yes |
Autophagolysosomal increase | No | Yes | Yes |
Cell shrinkage | Yes | No | No |
Physiological hallmark | Apopt. PCD | Non-Apopt. PCD (Autosis) | Thapsigargin |
|---|---|---|---|
Caspase dependent | Yes | No | No |
