Fig. 2: Functional experiments were performed to elucidate the involvement of histone lactylation in the malignant biological behavior of PC cells. | Cell Death Discovery

Fig. 2: Functional experiments were performed to elucidate the involvement of histone lactylation in the malignant biological behavior of PC cells.

From: Demethylzeylasteral suppresses the expression of MESP1 by reducing H3K18la level to inhibit the malignant behaviors of pancreatic cancer

Fig. 2

A, B The expression levels of Pan Kla, H3K18la, Bax and Bcl2 in PANC-1 and ASPC-1 cells after LDHA silencing were detected by western blot. Colony formation (C) transwell invasion (D) CCK-8 (E) wound-healing (F) and EdU (G) assays were used to explore the effects of H3K18la inhibition on the proliferation, migration and invasion of PC cells. All data are shown as the mean ± SD of at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, vs. NC. #p < 0.05, ##p < 0.01, ###p < 0.001, vs. si-LDHA.

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