Fig. 7: Summary of the anti-ferroptotic effects of hydroxyindoles.
From: The role of hydroxyindoles in protecting neuronal cultures from ferroptosis
Erastin, RSL3, and FINO2 promote ferroptosis by increasing the production of lipid peroxides. Among the hydroxyindoles, 3-hydroxyindole (3-HI) is the most effective inhibitor of ferroptosis, outperforming other hydroxyindoles such as 6-hydroxyindole (6-HI), 7-hydroxyindole (7-HI), serotonin, and the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA). Interestingly, 6-HI can increase glutathione levels, but this enhancement likely does not contribute to its anti-ferroptotic function.
