Fig. 3: Evaluation of inflammasome recruitment and activation in hAMSC after 24 h of exposure to increasing BPA concentrations. | Cell Death Discovery

Fig. 3: Evaluation of inflammasome recruitment and activation in hAMSC after 24 h of exposure to increasing BPA concentrations.

From: Bisphenol-A disrupts mitochondrial functionality leading to senescence and apoptosis in human amniotic mesenchymal stromal cells

Fig. 3

Inflammasome formation and activation were assessed by examining the genetic expression of both structural and functional components of the complex (NLRP3, NLRC4, AIM2, ASC, caspase 1, IL-1β) (Fig. 3) and the secretion of effector protein (IL-1β) (Supplementary Table 1) after exposure to increasing BPA concentrations (0.05, 0.1, 0.2, 0.3, 0.35, and 0.4 μM) with or without ATP (1.5 mM). The figure illustrates alterations in gene expression, presented as fold-change relative to the control condition (MetOH). Histograms represent the mean values ± SD from n = 3 independent experiments. Statistical analysis was performed versus the control condition: p < 0.01(**), p < 0.001(***), p < 0.0001(****).

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