Fig. 7: Microarray analysis to confirm treatment-induced changes in LAN-1 and CHLA-90 cells on a transcriptional level. | Cell Death Discovery

Fig. 7: Microarray analysis to confirm treatment-induced changes in LAN-1 and CHLA-90 cells on a transcriptional level.

From: CDK inhibitors promote neuroblastoma cell differentiation and increase sensitivity to retinoic acid—a promising combination strategy for therapeutic intervention

Fig. 7: Microarray analysis to confirm treatment-induced changes in LAN-1 and CHLA-90 cells on a transcriptional level.The alternative text for this image may have been generated using AI.

A Venn diagrams illustrate the number of genes that were differentially expressed after receiving RA (RA vs. Ctrl), fadraciclib (Fa vs. Ctrl), and the combination (Combi vs. Ctrl). Therefore, the data from the two cell lines LAN-1 and CHLA-90 were combined to eliminate the effects of the individual cell lines on the therapy. This was done to determine if the treatment itself can regulate the specific gene in both cell lines. Each circle represents the respective gene sets, with the default settings of a Benjamini–Hochberg adjusted P value < 0.05. B, C The 55 probe sets (mapping to 47 and 58 genes) in the center of the DEGs are depicted in the heatmap. B LAN-1 cells and (C) CHLA-90 cells.

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